Repetitive Strain Injury (RSI) Pain in the wrist and hand is usually from repeated movements, such as excessive computer keyboarding and mouse use, lifting and carrying babies and children, playing musical instruments and tasks involving repetitive wrist and finger activity. If the muscles of the forearm, wrist and hand are weak or tight, the chances of injury are greater. Tendons and ligaments in the wrist and fingers become inflamed and scarred as a result of overuse. When